Journal: Signal Transduction and Targeted Therapy

Article Title: p53: from understanding its structure to advances in therapeutic targeting

doi: 10.1038/s41392-025-02549-5

Figure Lengend Snippet: Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes CP31398, APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com

Article Snippet: Pfizer obtained CP31398 by screening a synthetic compound library.

Techniques: Mutagenesis